Even though the show is called 'Childrens Hospital,' we don't use kids a lot. They always want a juice box or a fruit roll up or a nap.

I think there are a lot of really funny things in 'The Descendants,' but there're a lot of different tones in that movie, in the same way that 'Transparent' has a lot of different tones.

There's no way to play it cool when you meet Paul McCartney. You just start sweating; you trip over your words. Everyone kind of reverts back to being a 10-year-old girl. You can't help it. He's one of the only people on planet Earth that everyone knows who he is. Everyone.

My mom has this thing where if I'm doing anything doing dirty or crazy, she sniffs it out and yells at me. But the good thing is my mom doesn't have cable, and so much of the stuff I've done was on cable, so many times she'll miss it. I tend to gloss over the crazier things I shoot.

I thought it was a joke at first, but the president did, in fact, authorize an autopen to sign the Patriot Act extension into law. Consider the dangerous precedent this sets. Any number of circumstances could arise in the future where the public could question whether or not the president authorized the use of an autopen.

You need to talk about sex with a sense of humor, especially because sex is a sensitive area for a lot of people.

There are so few good comedy sequels. The only one in recent memory that's good is '22 Jump Street.' It's a hard genre.

When someone pitches a joke for a character that is just perfect, and you can imagine that actor reading that line at your table read or on the set, it's like the sound of a snap snapping into place.