I've had a very unusual background in science - not the usual route of planning on being a scientist from age 3. I think my story shows that success is more about personal motivation and determination than it is about where you were born or what your economic status was.

In the past, geneticists have looked at so-called disease genes, but a lot of people have changes in their genes and don't get these diseases. There have to be other parts of physiology and genetics that compensate.

My early years were hardly a model of focus, discipline, and direction. No one who met me as a teenager could have imagined my going into research and making important discoveries. No one could have predicted the arc of my career.

If I could change the science system, my prescription for changing the whole thing would be organising it around big goals and building teams to do it.

You have no power at all if you do not exercise constant power.

Now in the 21st century, the boundaries separating chemistry, physics, and medicine have become blurred, and as happened during the Renaissance, scientists are following their curiosities even when they run beyond the formal limits of their training.

I am the least intimidating person. I think I would have done better in my career if I were a little more intimidating. Even the maid who comes to work for me once a week has found out that she can just trample over me... I'm a Cancer! We are not ferocious people.

The reality is: By the time swine flu got on the radar screen of global public health, it had already spread. It was already in the States, it was in Mexico, it was in New Zealand. By the time it reaches that point, you've lost the ability to contain it.