I turned 65 last year, and each year I get more and more interested in human health. For most people it happens around age 50, but I've always been a slow learner. It's critical in terms of the cost of health care.

I've had a very unusual background in science - not the usual route of planning on being a scientist from age 3. I think my story shows that success is more about personal motivation and determination than it is about where you were born or what your economic status was.

In the past, geneticists have looked at so-called disease genes, but a lot of people have changes in their genes and don't get these diseases. There have to be other parts of physiology and genetics that compensate.

My early years were hardly a model of focus, discipline, and direction. No one who met me as a teenager could have imagined my going into research and making important discoveries. No one could have predicted the arc of my career.

My scientific qualifications are relatively scant. I like science. I try really hard to educate myself about it, but in the end, if something has to go 'boom,' and it would probably only go 'fwoosh,' I am relatively unconcerned about that, which is a sin, but not, I think, a grave one.

Moonshots live in that place between audacious projects and pure science fiction.

In the last fifty years science has advanced more than in the 2,000 previous years and given mankind greater powers over the forces of nature than the ancients ascribed to their gods.

Much public thinking follows a rut. The same thing is true in science. People get stuck and don't look in other directions.