The most valuable lesson I learned in dealing with the ups and downs was to invest in my employees - to do all I could for them when the times were good.

Innovation is all about people. Innovation thrives when the population is diverse, accepting and willing to cooperate.

Entrepreneurship is like a computer game in which you have to master every level before achieving success. Startups repeatedly stumble and have to go back to the drawing board. The best way to skip some levels and to increase the odds of survival is to learn from others who have already played the game.

I used to have an obsession with building businesses and forgot about building health. I was focused on the destination instead of the journey. I caution you to not do the same.

You lose your home, you are much more likely to lose your job the year following. The reason for that comes back to the bandwidth problem: You're so focused on this event that you're making mistakes at work; you can relocate further from work, which can increase your tardiness and absenteeism and cause you to lose your job.

Anybody who can afford a box of business cards can afford a Web site. Any company with an 800 number can move its services to the Web for peanuts by comparison. The extreme case of corporate promotion is to strip away all other aspects of your business and sell goods or services via the Net alone, as amazon.com has done with books.

You should just enjoy it, but as soon as you decide that it is going to be your career, no matter whether you want to be a doctor or an architect or anything else, you need to work 5 hours a day.

In my career, there have been many things I am fortunate enough to be proud of. Yet one of the things I feel most strongly about is the culture we created during the ten years I was at Aetna, and its enduring impact.