An entrepreneur must deal with more uncertainty than a professional with a well-defined role.

When I was starting out, I followed along the path that seemed to be marked out for me - from high school to college to law school to professional life.

People don't want to believe that technology is broken. Pharmaceuticals, robotics, artificial intelligence, nanotechnology - all these areas where the progress has been a lot more limited than people think. And the question is why.

Credentials are critical if you want to do something professional. If you want to become a doctor or lawyer or teacher or professor, there is a credentialing process. But there are a lot of other things where it's not clear they're that important.

Twitter is the most impulsive form of social media, but it's still the most celebrated among politicians and pundits within the Beltway, which is curious, since it can destroy any sense of privacy.

I'm always interested in what you can do with technology that people haven't thought of doing yet. I think that's sort of a characteristic of the way I've worked ever since I started.

New forms of media - first movies, then television, talk radio and now the Internet - tend to challenge traditional codes of conduct. They flout convention, shake up the status quo and sometimes provoke outrage.

Many different relationships among patients, doctors, and drugs are possible and desirable. As in so many other areas of life, the Internet encourages experimentation. Questionnaire-based pharmacies operate between the traditional prescription and over-the-counter models.