The most irresistible charm of youth is its bubbling enthusiasm. Youth sees no darkness ahead - no defile that has no outlet - it forgets that there is such a thing as failure in the world and believes that mankind has been waiting all these centuries for him to come and be the liberator of truth and energy and beauty.

Every youth owes it to himself and to the world to make the most possible out of the stuff that is in him.

What is needed by him who would succeed in the highest degree possible is careful planning. He is to accumulate reserved power, that he may be equal to all emergencies.

With five chances on each hand and one unwavering aim, no boy, however poor, need despair. There is bread and success for every youth under the American flag who has energy and ability to seize his opportunity.

Famous pivot stories are often failures but you don't need to fail before you pivot. All a pivot is is a change is strategy without a change in vision. Whenever entrepreneurs see a new way to achieve their vision - a way to be more successful - they have to remain nimble enough to take it.

I don't care about commercial success. I get to do what I love and communicate whatever I want.

If we can actually decrease the failure rate from nine out of 10 drugs failing in clinical trials and instead have seven out of 10 instead failing, that is a major victory for drug discovery and for people having better therapy.

I've stopped apologizing to myself for having this great period of success and financial acceptance.