I was a very efficient doctor. I would get rewarded with a lot more patients. By the end of my medical career, I had maybe 2,000 patients in my practice.

I wasn't sued out of medicine, I wasn't arbitrated out of the profession.

I always say 'Knocked Up' opened the doors, and 'Hangover' just burst it wide open. To this day, it's still surreal. And my wife's a doctor. All our friends are doctors - our close friends. And it's just that I have an odd job now. I think I'm like a doctor who had a detour, and I just have an odd job.

I never let on I was a comedian. I never acted out. It was really important to me, like, to not be Patch Adams. I was so super serious as a doctor, I would bark orders to my nurses. I was hard-core. I wanted to make sure I did my job right. I was perfectly trained to be a physician. You know, it wasn't a fluke. I worked hard at it.

Your chemistry with your co-actors is more important in a comedy. You can't leave it to your performance alone. So many things have to fall into place to make people laugh.

I'm really not feeling one way or the other with comedy or drama, I'm just sort of doing projects that I've been finding really fun to be a part of.

So when you tell a joke, you want to make someone laugh, or if you tell a story about someone who had a heart attack, it may be because you want the listener to exercise. Stories are tools to create social cohesion and to get humans to strategize together.

On stage you look much larger than you are. You can have subtle changes of timing; how you place a punch line in a joke or movement or emotion according to an audience.