I was a very efficient doctor. I would get rewarded with a lot more patients. By the end of my medical career, I had maybe 2,000 patients in my practice.

I wasn't sued out of medicine, I wasn't arbitrated out of the profession.

I always say 'Knocked Up' opened the doors, and 'Hangover' just burst it wide open. To this day, it's still surreal. And my wife's a doctor. All our friends are doctors - our close friends. And it's just that I have an odd job now. I think I'm like a doctor who had a detour, and I just have an odd job.

I never let on I was a comedian. I never acted out. It was really important to me, like, to not be Patch Adams. I was so super serious as a doctor, I would bark orders to my nurses. I was hard-core. I wanted to make sure I did my job right. I was perfectly trained to be a physician. You know, it wasn't a fluke. I worked hard at it.

Any comic is a tragic soul. Comedy is one of the things that allows one to survive. Particularly if one has been in the process of separating off the emotions, it's one place you can process them.

Humor is a serious thing. I like to think of it as one of our greatest earliest natural resources, which must be preserved at all cost.

I have always been more relaxed around comedy.

The Internet is a great place to find unconventional comedy that you can't find anywhere else.