This is largely the methodology I've used throughout my career - that is, starting with a question as to what might be the properties of a set of compounds that could be invented which were unusual and unpredictable. Many times I've felt a bit like Columbus setting sail.

An investigator starts research in a new field with faith, a foggy idea, and a few wild experiments. Eventually the interplay of negative and positive results guides the work. By the time the research is completed, he or she knows how it should have been started and conducted.

To retain my fascination with chemistry, I have had to change my research fields about every 10 years.

By the time I entered college, I had decided not to have children, a decision that was never regretted. Accordingly, I was careful to court only girls who wanted to have professional careers.

When you start using test audiences, it becomes more scientific than it is about the work itself, and that's boring.

Opposites generally create intense chemistry. There are more chances of fireworks when different people are together than similar personalities.

I was really aware, even while it was happening, that the discovery of arts education in my life sort of saved my life.

GIS, in its digital manifestation of geography, goes beyond just the science. It provides us a framework and a process for applying geography. It brings together observational science and measurement and integrates it with modeling and prediction, analysis, and interpretation so that we can understand things.