Aaron Ciechanover

The evolvement of proteolysis as a centrally important regulatory mechanism is a remarkable example for the development of a novel biological concept and the accompanying battles to change paradigms.

We are a country that lacks riches. The Jewish brain, that's what we have. Everything that we've had and will have in this country is the direct and clear product of higher education. If we harm this system, we will drastically decline and cease to exist.

We need to save the education system. We need to remove education from the framework of the political parties that rule in the State of Israel. We need to increase the allocation of long-term national resources to education and never touch them - no matter what.

The scale of time for a politician runs between one primary and the next, and in Israel, this means two to three years because elections almost never take place once every four years as stipulated by law. The timetable for a system of research is completely different.

The problem of different sensitivities of distinct protein groups to lysosomal inhibitors has remained unsolved and may have served as an important trigger in the future quest for a non-lysosomal proteolytic system that may be involved in at least certain aspects of intracellular protein degradation.

We are paying the price for living longer, collecting degenerative diseases along the way. Cancer is only one. Others are heart and brain diseases like Alzheimer's and Parkinsons.

We discovered a mechanism which is like the garbage machine of the body. We need to remove damaged proteins and create new ones in their place, and we discovered the machine that does this.